I vermectin and a bamectin members of the avermectin family of compounds were introduced to the market in the 1980s as a veterinary antiparasitic drug and agricultural pesticide respectively their acceptance and commercial success have been remarkable both are highly effective and in worldwide use. Abamectin ec50 15 um and ivermectin ec50 06 um are fermentation products generated by a soil dwelling actinomycete streptomyces avermitilis whereas berberine ec50 18 um is a plant derived isoquinoline alkaloid. I vermectin and a bamectin members of the avermectin family of compounds were introduced to the market in the 1980s as a veterinary antiparasitic drug and agricultural pesticide respectively. Ed ivermectin and abamectin springer new york ny pp 113 130 10 ricardo pena silva stephen b duffull andrew c steer sandra x jaramillo rincon amanda gwee et al 2020 pharmacokinetic considerations on the repurposing of ivermectin for treatment of covid 19 br j clin pharmacol 11 clinicaltrialsgov identifiers nct 04425850 y nct 04425863 12 khalil ansarin ramin tolouian